UNIVERSITY OF HERTFORDSHIRE
	     COMPUTER SCIENCE RESEARCH COLLOQUIUM

			    presents


    "An Interneuron Circuit Reproducing Essential Spectral
		 Features of Field Potentials"


		     Dr. Reinoud Maex

	(Royal Society Wolfson Biocomputation Research Lab,
     School of Computer Science, University of Hertfordhshire)

		     9 April 2018 (Monday)

			   1 - 2 pm


		  Hatfield, College Lane Campus
			Seminar Room C408

		  Everyone is Welcome to Attend

		  Refreshments will be available


Abstract:


Recent advances in engineering and signal processing have renewed the
interest in electro-encephalography (EEG).
In this talk, I will present results from a computational study showing
that a model circuit of interneurons, coupled via both GABA(A) receptor
and electrical synapses, reproduces many features of the power spectrum
of the EEG, such as a 1/f power scaling at low	frequencies (< 15 Hz),
power accumulation in the gamma-frequency band (30--100 Hz), and a robust
alpha rhythm (7-13 Hz) in the absence of stimulation.
The low-frequency 1/f power scaling depends on the strong reciprocal
inhibition between the interneurons, whereas the alpha rhythm is generated
by the electrical coupling of these intrinsically active neurons.
As in previous studies, the gamma power arises through the amplification
of single-neuron spectral properties, owing to their refractory period,
by parameters that favour neuronal synchrony, such as delayed inhibition.
Given the ubiquity of electrically coupled interneuron circuits in the
mammalian brain, they may be major determinants of the EEG rhythm.


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Hertfordshire Computer Science Research Colloquium
http://cs-colloq.cs.herts.ac.uk