UNIVERSITY OF HERTFORDSHIRE
		COMPUTER SCIENCE RESEARCH COLLOQUIUM

			     presents

           "An Overview of New Genomic Sequencing Methods"

                	Dr. Rene te Boekhorst 
		    (School of Computer Science,
		    University of Hertfordshire)


		      14 January 2009 (Wednesday)

		     Lecture Theatre E350	
	     Hatfield, College Lane Campus
			      3 - 4 pm

	    Coffee/tea and biscuits will be available.

		   Everyone is Welcome to Attend



Abstract:


Since the identification of all the 5368 building blocks (nucleotides) 
of the DNA of bacteriophage \phi x174 (in 1977 by Sanger), an increasing 
number of genomes of differenced species have been sequenced, analysed 
and stored in public databases. A landmark was the sequencing of the 
human genome (finalized in 2003). The Human Genome Project took 13 
years because the ingenious, but laborious and time consuming sequencing 
methods available at that time had to be applied to ~3 billion nucleotides.

Recently, an even more ambitious project has seen the light of the day. 
The "1000 Genomes Project" is an international research consortium that 
has been formed to create the most detailed picture of human genetic variation 
to date. It will involve sequencing the genomes of at least a thousand people 
from around the world, but for this to be feasible much faster sequencing 
methods are required.  In this talk I will present an overview of the 
so-called "Next Generation Sequencing Methods"  that have recently been 
developed and claim to meet the demands of high throughput endeavours like the
"1000 Genome Project".

Based on the projects of four of our MSc students Bioinformatics, which they 
did in cooperation with the Wellcome Trust Sanger Institute at Cambridge, I 
will outline some of the possibilities and problems of in particular the 
Illumina (Solexa) and SOLiD "NextGen" platforms.


--------------------------------------------------
Hertfordshire Computer Science Research Colloquium
http://homepages.feis.herts.ac.uk/~nehaniv/colloq