UNIVERSITY OF HERTFORDSHIRE            
       COMPUTER SCIENCE RESEARCH COLLOQUIUM       
                                                  
                     presents   
					                   
      "Heterogeneous models of large-scale resting-state
	        networks in health and disease"                
                      				                        
                Dr. Christoph Metzner                  
                                                  
         (Technische Universitaet Berlin)           
                                                  
                7 October 2020                  
                                                  
                  13:00 - 14:00                   
                                                  
                   Over Zoom          
		 
Abstract

Understanding the genesis of spatially and temporally structured brain rhythms is a crucial matter in neuroscience. These spatiotemporal dynamics are shaped by structural constraints on regional interactions, as well as intrinsic dynamical properties of those components. Over the last decade, network neuroscience has developed and applied many tools to identify and characterize these dynamics. Recently, large-scale computational models have further demonstrated how intrinsic microcircuit properties across cortex shape large-scale structure-function relationships.
 
In this talk, I will summarize our efforts to use tools from network neuroscience (graph and control theory) together with heterogeneous large-scale computational models to relate microcircuit alterations in schizophrenia to deficits in resting-state networks identified by MEG and fMRI. I will further present neurolib (https://github.com/neurolib-dev/neurolib), a Python simulation framework for whole-brain modelling that we have developed in our group.